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News

ABN Clinical Research Fellowship deadline: Sunday 18 November 2018.

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Events

ABN Annual Meeting 2019: 21 - 23 May 2019 - The EICC, Edinburgh

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Bo Sun

Investigating T-Lymphocyte Function across Neuronal Surface Antibody associated Diseases

An increasingly common group of autoimmune diseases of the brain and nervous system are now recognised to be caused by antibodies. Antibodies are produced by a population of white blood cells called B-cells and, normally, play an important role in the body’s ability to fight infection. However sometimes the immune system becomes confused and attacks our own body in a process termed ‘autoimmunity’.

My research aims to explore and understand why the immune system attacks our own body in neurological diseases caused by antibodies. I will be focusing on a group of white blood cells called T-cells, which regulate the production of the B-cells producing self-attacking antibodies. If we can identify the reasons why these immune safety nets fail, we can then explore ways in which to manipulate them to stop the disease process. Taking samples from patients with varying degrees of disease severity, I will systematically isolate subgroups of T-cells and directly assess whether they alter autoantibody production by B-cells. This will provide valuable information into how T-cells fail to stop disease-causing B-cells. It will also identify cell subsets that could be targeted to ameliorate these diseases. This is a viable therapeutic aim, as drugs already exist to target these cell types and could be translated to this cohort within 3 years. By working in a group with a very active clinical programme, I will also learn to assess and

treat patients with these illnesses.

 

News

ABN Clinical Research Fellowship deadline: Sunday 18 November 2018.

Read More

Events

ABN Annual Meeting 2019: 21 - 23 May 2019 - The EICC, Edinburgh

Read More