Dr Ian Galea, University of Southampton
Dr Rachel Kneen, University of Liverpool
Dr Benedict Michael, University of Liverpool
Prof Sarah Pett, UCL
Dr Rhys Thomas, Newcastle University
Contact point: email@example.com / www.coronerve.com
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We are looking to collate the serious and rare neurological
complication of COVID-19.
The COVID-19 pandemic is an evolving national emergency in
which a significant proportion of the population are expected to be infected.
The experience of past pandemics, notably influenza subtype H1N1 in 1918 and
2009, suggests that neurological complications may occur. Though the proportion
may be small, given the large number of infections the collective burden may be
patient (age >18 years).
• History of
laboratory-confirmed of COVID-19 infection, or suspected infection,
irrespective of clinical signs and symptoms
neurological disorder, occurring contemporaneously or following COVID-19
infection implicated as possible cause of neurological disorder by a
The reporting neurologist will be sent a short case
reporting form. Given the unprecedented strain the NHS is currently facing,
this form has been kept purposely brief so as not to add to the workload of
busy clinicians and staff-depleted teams, and is essentially a screening
document. A minimum of information required to later identify the patient is
requested, encrypted via a scrambling algorithm. Since no openly identifiable
information is shared, consent is not required at this point. A similar strategy
is already in use by the UK Renal Registry, for example.
At a later point, the local clinical research team linked to
the reporting neurologist may be contacted and asked to either consent the
patient or obtain assent from their significant other, using approved forms
supplied by the central study team. Once consented, clinical details such as
demographics, past medical history, symptoms, signs, test results, treatment,
and progress will be gathered from the reporting neurologist or their team
using a standardised case report form.
We have also partnered with the BPNA to identify cases under
the age of 18y, the BNPA to identify neuropsychiatric complications, BASP to
ensure we are notified of acute cerebrovascular presentations, and NACCS so
that people primarily managed by neuro-intensivists are reported.