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Trials & Surveys


  • Recruitment open for the MS-STAT2 trial in Secondary Progressive Multiple Sclerosis:

Jeremy Chataway (Chief Investigator) and the MS-STAT2 team would be extremely grateful if members of the ABN could put forward suitable patients for the ongoing MS-STAT2 study. Routes of referral include:

1. Directing patients to the trial registration website,

2. Or emailing the study team at

This NIHR, UK and US MS society funded, academically-led phase 3 trial, will recruit 1180 patients with secondary progressive multiple sclerosis (SPMS) at over 30 sites across the UK and Ireland. This builds upon results from the original MS-STAT phase 2 study, which demonstrated high dose simvastatin reduced the annualised rate of brain atrophy by 43% compared to placebo over 2 years1.

Key inclusion criteria include: a diagnosis of SPMS in patients aged 25-65; evidence of disability progression over the previous 2 years; an EDSS score 4.0-6.5 (significant disability but able to walk approximately 500m, to those who require walking aids to walk at least 20m). Key exclusion criteria include current use of disease modifying therapies, primary progressive MS or current use of any statin. The primary outcome measure will be time to initial disability progression. The intervention will be 80mg simvastatin or placebo, randomised 1:1 over a 3 year trial. Active study sites are outlined on the map

Ref: 1. Chataway, J et al. The Lancet 383.9936 (2014): 2213-2221.

MIROCALS (Modifying Immune Response & OutComes in ALS)
MIROCALS ( has now completed recruitment and the final efficacy analysis is scheduled for late 2021. Please direct any queries about the study to: Professor P Nigel Leigh, Chief Investigator, e-mail:, or:



Clozapine Survey - click here

This is a short survey and should take approximately 5-10 minutes to complete.

Survey closes 5pm Monday 20 April 2020.

The recent Parkinson's UK 2019 Audit found that only around a third of participating services had access to a clozapine pathway. Parkinson's UK is supporting a working group of clinicians, formed as part of the Mental Health Hub within the UK Parkinson's Excellence Network, to look at access to clozapine to treat psychosis in Parkinson's.

We are keen to find out how services with access to a clozapine pathway operate and what the barriers are for services without access to a clozapine pathway.

If you have any questions or concerns about the survey, please contact Sam Freeman Carney, Senior Policy and Campaigns Adviser (mental health and dementia) on or 020 7963 9394.

Conversion disorder survey
We would be grateful if you could take 10 minutes to complete this short online survey on conversion disorder (functional neurological symptoms disorder) if you have not already done so. 
The ABN supported this research previously in 2009, with an excellent response rate from members.  The results were published in the Journal of Neurology, Neurosurgery and Psychiatry (Kanaan RA, Armstrong D, Wessely SC.  Neurologists' understanding and management of conversion disorder.  JNNP 2011 Sep;82(9):961-6).  We are keen to look at how things may have changed over the last decade.  All responses will be anonymous. To complete the survey, please click here.

  • Placebo survey (10 minutes)
    Our clinical research training fellow Dr Anne-Catherine Huys is running a survey on doctors’ and patients’ opinion on whether or not placebo treatments should be used in clinical practice; and on what the current clinical practice is. The survey only takes 10 minutes, is anonymous and can be done by clicking this link.


  • Delivery of the diagnosis of a progressive neurological condition - PhD Project
  • Neurologists who deliver the diagnosis for conditions such as MND, MS, HD, PD are kindly asked to complete this short survey about their practice and perspectives on diagnosis communication for a PhD project at Lancaster University - Link
  • In addition, neurologists who would like to participate in a qualitative study on the same project and talk about their experiences of breaking bad news can find more information here and send an email to



Researchers at the University of Southampton are looking for neurologists to take part in a MS research project

The project is exploring your experiences of communicating prognosis to patients with Multiple Sclerosis. Participation will involve a telephone interview at a time and place that is convenient for you and the interview is predicted to last around 45 minutes to an hour. In return for your participation, you will receive a £15 Amazon voucher and a certificate stating that you have helped with this research, which might be useful in your professional appraisal or revalidation. We would also be happy to provide a transcript of the conversation if you wish, for use as an example of reflection on one’s practice. The interview will provide an opportunity for reflection that may be useful for your appraisal. Ultimately, the research aims to contribute towards understanding and improving prognosis communication and Healthcare Professional-Patient relationships. If you are interested in participating or simply want to find out more, please contact Samantha Hornsey at the University of Southampton (

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